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Indeed, mi RNA has showed potential value in cancer diagnosis and therapy.
Mutations in the RB1 gene are responsible for most cases of RB.
To meet the desirable requirements, the use of micro fluidic devices, which conveys mi RNA molecules to bind with locked nucleic acid (LNA) probe in micro channels, can be an attractive choice because it can reduce the assay time.
Based on this background knowledge, the study was aimed towards the development of highly sensitive and low cost diagnostic tool for detection of oncogenic RB from the serum of RB patients.
Only about 25% of the children born with this gene change inherit it from a parent.
In about 75% of children the gene change first occurs during early development in the womb.